Polyamine-Based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulate in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents-河南大学药学院

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Polyamine-Based Pt(IV) Prodrugs as Substrates for Polyamine Transporters Preferentially Accumulate in Cancer Metastases as DNA and Polyamine Metabolism Dual-Targeted Antimetastatic Agents

2021年04月03日 10:50 作者：马静 返回列表

本文首次设计并合成基于调控肿瘤细胞多胺微环境的新型四价铂多胺配合物，并同时表现出明显优于顺铂的抗肿瘤生长及转移的活性。进一步的机制研究表明，高精脒铂通过p53/SSAT/β-catenin和PAO/ROS/GSH/ GSH-Px途径下调Put, Spd, Spm含量实现了铂类药物的靶向性。

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