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张亚宏

时间:2017年06月24日    来源:    作者:    阅读:

1. 个人信息(Personals):

  女,1982.01,博士,副教授,zhangyahong_131@163.com

2. 受教育经历 (Educational Experience) (从大学本科开始,按时间倒排序):

  2004.09-2009.07,沈阳药科大学,博士研究生                    2000.09-2004.07,沈阳药科大学,本科

3. 工作经历(Professional Experience)(按时间倒排序):

  2009.07-至今,河南大学天然药物与免疫工程重点实验室,副教授

4. 研究兴趣(Research Interests):

  研究方向:1)抗肿瘤药物的高通量筛选研究;2)抗肿瘤药物机制研究;3)抗肿瘤药物作用新靶点研究

5. 承担项目情况(Financial Supports)(包括项目名称,批准号,金额,起止年月,基金来源,本人角色)

  1)多胺通过调节p-糖蛋白诱导肿瘤细胞多药耐药的机制研究,U1404819,30万,201501-201701,国家自然科学基金,主持
  2)蒽醌衍生物抗肝癌作用机制研究,132300410228,201301-201601,2013-2016,河南省科技厅基础与前沿技术研究项目,主持
  3)靶向性多胺-萘酰亚胺缀合物对肝癌细胞PKC信号通路调控的机制研究,20100470995,3万,2010-2013,博士后基金,主持

6. 代表性论著(Publications)

[1] Zhang YH, Zhang N, Li YK, Lu YL, Li MG*, Chen DY. Synthesis, Crystal Structures, and Cytotoxicity of Thiophene-2-carbaldehyde N(4)-Cyclohexylthiosemicarbazone and Its Diorganotin(IV) Complex. Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry,45, 191-195, 2015

[2] Wang JH, Cheng PF, Luo TW, Wang ZY, Zhang YH *, Zhao J *. Synthesis and Preliminary Biological Evaluation of Polyamine-aniline Acridines as P-glycoprotein Inhibitors. Medicinal Chemistry, 10(5), 506-511, 2014

[3] Wang JH, Luo TW, Li SB, Zhang YH*, Wang CJ, Zhao J*. Synthesis structure-activity relationship and biological activity of acridine derivatives as potent MDR-reversing agents, Curr Med Chem, 20(32), 4070-4079, 2013

[4] Zhang YH, Wu YL, Tashiro S, Onodera S, and Ikejima T*. Reactive oxygen species contribute to oridonin-induced apoptosis and autophagy in human cervical carcinoma HeLa cells, Acta Pharmacol Sin, 32, 1266-1275, 2011

[5] Zhang YH, Wu YL, Wu D, Tashiro S, Onodera S, and Ikejima T*. NF-κB facilitates oridonin-induced apoptosis and autophagy in HT1080 cells through a p53-mediated pathway, Arch Biochem Biophys, 489, 25-33, 2009

[6] Zhang YH, Wu YL, Tashiro S, Onodera S, and Ikejima T*. Involvment of PKC signal pathway in oridonin-induced autophagy in HeLa cells: a protective mechanism against apoptosis, Biochem Biophys Res Commun, 378, 273-278, 2009

[7] Zhang YH, Wu YL, Cheng Y, Zhao ZK, Tashiro S, Onodera S, and Ikejima T*. Fas-mediated autophagy requires JNK activation in HeLa cells, Biochem Biophys Res Commun, 377, 1205-1210, 2008

[8] 张亚宏,甘莹,郭子华,谢松强*. 紫草素通过ROS /p38 信号通路诱导人宫颈癌HeLa 细胞凋亡, 中国药理学通报, 27(6), 864-867, 2011

[9] 张亚宏,郭敬功,郭子华,谢松强*. 白藜芦醇通过激活p38-p53通路诱导人乳腺癌MCF-7细胞凋亡, 药学学报, 46(11), 1332-1337, 2011

[10] 张亚宏,甘莹,齐建国*,王建红*.米托蒽醌通过活性氧诱导大鼠肝癌RH35细胞凋亡的研究, 中国畜牧兽医,43(12), 3245-3250, 2016