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余云舟

时间:2017年06月24日    来源:    作者:    阅读:

1. 个人信息(Personals):

  男、1978.10,博士,硕士生导师,副研究员/副教授,Email:yunzhouyu@163.com

2. 受教育经历 (Educational Experience)(从大学本科开始,按时间倒排序):

  2003.09-2006.07,军事医学科学院生物工程研究所,博士研究生

  2000.09-2003.07, 军需大学,硕士研究生

  1996.09-2000.07,军需大学,本科

3. 工作经历(Professional Experience)(按时间倒排序):

  2012.08-至今,军事医学科学院生物工程研究所,副研究员/副教授

  2010.08-2012.07:军事医学科学院生物工程研究所,副研究员(资格)

  2006.07-2010.07,军事医学科学院生物工程研究所,助理研究员

4. 研究兴趣(Research Interests)

  研究方向:1) 重组基因工程疫苗与免疫调节机制研究;2) 阿尔茨海默病防治药物与机制研究。

5. 承担项目情况(Financial Supports)(包括项目名称,批准号,金额,起止年月,基金来源,本人角色)

[1] CpG化修饰对炭疽新型复制子DNA疫苗免疫调节作用研究,7102125,11万元,201001-201212,北京市自然科学基金,主持

[2] 载体骨架CpG化修饰对新型复制子DNA疫苗免疫调节作用研究,30901375,20万元,201001-201212,国家自然科学基金,主持。

[3] 重组Aβ1-15串联体疫苗免疫治疗阿尔茨海默病效应研究,7122130,北京市自然科学基金,11万元,201201-201412,主持

[4] 阿尔茨海默病新型重组亚单位疫苗研究,2012ZX09301003-001-005-032,国家科技重大专项子课题,8万元,201201-201512,主持

[5] 四价XX抗毒素的研制,国家科技重大专项,548万元,201401-201612,主持

6. 代表性论著(Publications)

[1] Yu YZ, Xu Q. Prophylactic immunotherapy of Alzheimer's disease using recombinant amyloid-β B-cell epitope chimeric protein as subunit vaccine. Hum Vaccin Immunother. 2016, 12: 2801–2804.

[2] Yu YZ, Liu S, Wang HC, Shi DY, Xu Q, Zhou XW, Sun ZW, Huang PT.A novel recombinant 6Aβ15-THc-C chimeric vaccine (rCV02) mitigates Alzheimer's disease-like pathology, cognitive decline and synaptic loss in aged 3 × Tg-AD mice. Sci Rep. 6:27175.

[3] Yu YZ, Liu S, Wang HC, Shi D, Xu Q, Zhou XW, Sun ZW, Huang PT. A Novel Aβ B-Cell Epitope Vaccine (rCV01) for Alzheimer's Disease Improved Synaptic and Cognitive Functions in 3 × Tg-AD Mice. J Neuroimmune Pharmacol. 2016, 11:657–668.

[4] Liu S, Shi DY, Wang HC, Yu YZ, Xu Q, Sun ZW. Co-immunization with DNA and protein mixture: A safe and efficacious immunotherapeutic strategy for Alzheimer’s disease in PDAPP mice. Scientific Reports, 2015, 5: 7771.

[5] Liu B, Shi DY, Chang SH, Gong X, Yu YZ, Sun ZW, Wu J. Characterization and immunological activity of different forms of recombinant secreted Hc of botulinum neurotoxin serotype B products expressed in yeast. Scientific Reports, 2015, 5: 7678.

[6] Yu YZ, Shi DY, Liu S, Gong ZW, Wang S, Sun ZW. Production and evaluation of a recombinant subunit vaccine against botulinum neurotoxin serotype B using a 293E expression system. Hum Vaccin Immunother, 2015, 11(2): 468-473.

[7] Yu YZ, Ma Y, Xu WH, Wang S, Sun ZW. Combinations of various CpG motifs cloned into plasmid backbone modulate and enhance protective immunity of viral replicon DNA anthrax vaccines. Med Microbiol Immunol, 2015,204:481-491.

[8] Yu YZ, Chao A, Wang WB, Chang Q, Liu S, Zhao M, Qiu WY, Pang XB, Xu Q, Sun ZW. Strikingly reduced amyloid burden and improved behavioral performance in Alzheimer’s disease mice immunized with recombinant chimeric vaccines by hexavalent foldable Aβ1-15 fused to toxin-derived carrier proteins. J Alzheimer Dis, 2014, 41:243-260.

[9] Yu YZ, Liu S, Ma Y, Gong ZW, Wang S, Sun ZW. Pentavalent replicon vaccines against botulinum neurotoxins and tetanus toxin using DNA-based Semliki Forest virus replicon vectors. Hum Vaccin Immunothe, 2014, 10:7, 1874-1879.

[10] Yu YZ, Guo JP, An HJ, Zhang SM, Wang S, Yu WY, Sun ZW. Potent tetravalent replicon vaccines against botulinum neurotoxins using DNA-based Semliki Forest virus replicon vectors. Vaccine, 2013, 31: 2427-2432.

[11] Yu YZ, Wang S, Bai JY, Zhao M, Chao A, Wang WB, Chang Q, Liu S, Qiu WY, Pang XB, Xu Q, Sun ZW. Effective DNA epitope chimeric vaccines for Alzheimer's disease using a toxin-derived carrier protein as a molecular adjuvant, Clin Immunol, 2013, 149: 11-24.

[12] Yu YZ, Li N, Ma Y, Wang S, Yu WY, Sun ZW. Three types of human CpG motifs differentially modulate and augment immunogenicity of non-viral and viral replicon DNA vaccines as built-in adjuvants. Eur J Immunol. 2013. 43: 228-39.