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司端运

时间:2017年06月23日    来源:    作者:    阅读:

1. 个人信息(Personals):男,1965年2月,博士研究生毕业,研究员,天津药物研究院释药技术与药代动力学国家重点实验室常务副主任。Email:sidy@tjipr.com

2. 受教育经历 (Educational Experience) (从大学本科开始,按时间倒排序):

  1998-2001,沈阳药科大学,药物分析学专业博士生

  1987-1990,中国药科大学,天然药物化学专业硕士生

  1980-1984,山东医学院药学系,药学专业本科生

3. 工作经历(Professional Experience)(按时间倒排序):

  2005-至今,天津药物研究院,研究员

  2003-2004,美国Burnham研究所,博士后

  2002-2003,法国INRA研究机构Dijon研究中心

  1984-2005,山东济宁医学院药学系,教师

4. 研究兴趣(Research Interests):

  药物代谢,药代动力学,新药评价

5.承担项目情况(Financial Supports)(包括项目名称,批准号,金额,起止年月,基金来源,本人角色)

[1] 基于生物药剂学分类的药物释药动力学研究,50万元,2017-2019,天津市平台及条件建设课题,主持

[2]创新药物非临床药物代谢动力学技术平台建设,2012ZX09304002,965万元,2012-2015,国家科技重大专项,主持

[3]创新药物非临床药物代谢动力学技术平台建设,2009ZX09304005,1106万元,2009-2010,国家科技重大专项,主持

[4]纳米药物载体增强药物导向性体内过程的研究,2006CB933303,240万元,2006-2010,国家973项目课题,主持

6. 代表性论著(Publications)

[1]Fan H, Hu Z, Li R, Dong S, Gu Y, Liu T, Si D, Liang G, Liu C. Metabolite identification of bentysrepinine (Y101), a novel anti-HBV agent in rats using a five-step strategy based on a combined workflow with two different platforms of liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:118-128. doi: 10.1016/j.jchromb.2016.12.008.

[2] Liu W, Wang X, Chen R, Zhang K, Li Y, Li Y, Si D, Gong J, Yin D, Wang Y, Wei Z, Yang M. Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration. Acta Pharm Sin B. 2016 Sep;6(5):468-474.

[3] Zhang A, Li Q, He X, Si D, Liu C. Interactions between Transporters and Herbal Medicines/Drugs: A Focus on Hepatoprotective Compounds. Curr Drug Metab. 2015;16(10):911-8.

[4] Wu W, Dong Y, Gao J, Gong M, Zhang X, Kong W, Li Y, Zeng Y, Si D, Wei Z, Ci X, Jiang L, Li W, Li Q, Yi X, Liu C. Aspartate-modified doxorubicin on its N-terminal increases drug accumulation in LAT1-overexpressing tumors. Cancer Sci. 2015 Jun;106(6):747-56. doi: 10.1111/cas.12672. Epub 2015 May 26.

[5] Wei H, Gu Y, Liu Y, Chen Y, Liu C, Si D. Quantitation of clevidipine in dog blood by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Nov 15;971:52-7.

[6] Li Y, Wu L, Gu Y, Si D, Liu C. Metabolism of aildenafil in vivo in rats and in vitro in mouse, rat, dog, and human liver microsomes. Drug Test Anal. 2014 Jun;6(6):552-62.

[7] Qin L, Zhang F, Lu X, Wei X, Wang J, Fang X, Si D, Wang Y, Zhang C, Yang R, Liu C, Liang W. Polymeric micelles for enhanced lymphatic drug delivery to treat metastatic tumors. J Control Release. 2013 Oct 28;171(2):133-42.

[8] Zou Q, Gu Y, Lu R, Zhang T, Zhao GR, Liu C, Si D. Development of an LC/MS/MS method in order to determine arctigenin in rat plasma: its application to a pharmacokinetic study. Biomed Chromatogr. 2013 Sep;27(9):1123-8.

[9] Fan H, Li R, Gu Y, Si D, Liu C. Quantitation of bentysrepinine (Y101) in rat plasma by liquid chromatography tandem mass spectrometry: application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Mar 15;889-890:103-9.

[10] Cai Y, Zhang Z, Fan K, Zhang J, Shen W, Li M, Si D, Luo H, Zeng Y, Fu P, Liu C. Pharmacokinetics, tissue distribution, excretion, and antiviral activity of pegylated recombinant human consensus interferon-α variant in monkeys, rats and guinea pigs. Regul Pept. 2012 Jan 10;173(1-3):74-81.

[11] Xia Y, Wei G, Si D, Liu C. Quantitation of ursolic acid in human plasma by ultra performance liquid chromatography tandem mass spectrometry and its pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Jan 15;879(2):219-24.

[12] Gu Y, Lu R, Si D, Liu C. Simultaneous determination of tegafur and gimeracil in human plasma by liquid chromatography/tandem mass spectrometry. Anal Sci. 2009 Oct;25(10):1211-5.

[13] Lu R, Gu Y, Si D, Liu C. Quantitation of catalpol in rat plasma by liquid chromatography/electrospray ionization tandem mass spectrometry and its pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Nov 1;877(29):3589-94.

[14] Gu Y, Si D, Gao J, Zeng Y, Liu C. Simultaneous quantification of psoralen and isopsoralen in rat plasma by ultra-performance liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study after oral administration of Haigou Pill. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):3137-43.

[15] Cheng T, Si D, Liu C. Rapid and sensitive LC-MS method for pharmacokinetic study of vinorelbine in rats. Biomed Chromatogr. 2009 Sep;23(9):909-11.

[16] Lin Y, Si D, Zhang Z, Liu C. An integrated metabonomic method for profiling of metabolic changes in carbon tetrachloride induced rat urine. Toxicology. 2009 Feb 27;256(3):191-200.

[17] Xu Y, Si D, Liu C. Determination of strychnine and brucine in rat plasma using liquid chromatography electrospray ionization mass spectrometry. J Pharm Biomed Anal. 2009 Feb 20;49(2):487-91.

[18] Wei G, Xiao S, Si D, Liu C. Improved HPLC method for doxorubicin quantification in rat plasma to study the pharmacokinetics of micelle-encapsulated and liposome-encapsulated doxorubicin formulations. Biomed Chromatogr. 2008 Nov;22(11):1252-8.

[19] Si D, Zhong D, Liu C. Screening for in vivo metabolites of isovalertatin family oligosaccharides in rats by liquid chromatography coupled to electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(22):3385-92.