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高春生

时间:2017年06月21日    来源:    作者:    阅读:

1. 个人信息(Personals):男,1970.04,药剂学博士,研究员,largedna@163.com

2. 受教育经历 (Educational Experience)(从大学本科开始,按时间倒排序)

  2003.09-2006.07 军事医学科学院,攻读药剂学博士学位

  1996.09-1999.07 军事医学科学院,攻读药剂学硕士学位

  1988.09-1992.07 第二军医大学药学院,攻读药学本科学位

3. 工作经历(Professional Experience)(按时间倒排序)

  1992.09-1996.09,军事医学科学院,毒物药物研究所研究实习员

  1999.09-2007.08,军事医学科学院,毒物药物研究所助理研究员

  2007.09-2014.08,军事医学科学院,毒物药物研究所副研究员

  2014.09-至今,军事医学科学院,毒物药物研究所研究员

  2010.07-至今,军事医学科学院,硕士生导师

  2015.07-至今,军事医学科学院,博士生导师

4. 研究兴趣(Research Interests)

  研究方向:1) 微粒控释给药系统;2)个体化制剂技术; 3)军用特需制剂技术。

5. 承担项目情况(Financial Supports)(包括项目名称,批准号,金额,起止年月,基金来源,本人角色)

  [1]常见化学ZDKD药物研究,2015ZX09J15104-003,1009万元,201501-201812,国家重大新药创制专项子课题,负责。

  [2]高新技术WQ损伤FZ药物集成研究,2014ZX09J14101,3100 万元,201401-201612,国家重大新药创制专项课题,负责。

  [3]盐酸7511注射液,2011ZXJ09305-4,162 万元,201101-201312,国家重大新药创制专项子课题,负责。

  [4]KQ自动注射针,2008ZXJ09002-007,239 万元,200810-201012,国家重大新药创制专项课题,负责。

  [5]魔力那班Z20060228创新药物研究,2006AA020605,150 万元,2006-2010,国家863重点课题子课题,负责。

  [6]菌群触发型结肠给药系统研究,01Q041,20 万元,2001-2005,军队十五医药卫生青年基金,负责。

  [7]基于粉末直压工艺的速释制剂研究,969020217,50 万元,1996-2001,国家九五科技攻关项目,负责。

6. 代表性论著(Publications)

  [1]Meiyan Yang, Wei Gong, Yuli Wang, Li Shan, Ying Li, Chunsheng Gao*. Bioavailability Improvement Strategies for Poorly Water-Soluble Drugs Based on the Supersaturation Mechanism: An Update. J Pharm Pharm Sci. 2016, 19(2): 208 – 225.

  [2]Yuli Wang, Meiyan Yang, Ruifang Shen, Shuai Shao, Lu Chen, Wei Gong, Li Shan, Chunsheng Gao*. Development of metoprolol tartrate-loaded sustained-release pellets: effect of talc on the mechanism of drug release. Pharm Dev Technol. 2016, http://dx.doi.org/10.1080/10837450.2016.1212881.

  [3]Gong W, Wang Y, Sun L, Yang J, Shan L, Yang M, Gao C*. Development of itraconazole liquisolid compact: effect of polyvinylpyrrolidone on the dissolution properties. Curr Drug Deliv. 2016, 13(3):452-461.

  [4]Gong W, Wang Y, Shao S, Xie S, Shan L, Yang M, Gao C, Zhong W. Preparation, Wang Y, Yu N, Guo R, Yang M, Shan L, Huang W, Gong W, Shao S, Chen X, Gao C*. Enhancing in vivo bioavailability in beagle dogs of GLM-7 as a novel anti-leukemia drug through a self-emulsifying drug delivery system for oral delivery. Curr Drug Deliv. 2016,13(1):131-142.

  [5]Yuli Wang, Jingjing Dai, Xinyi Chang, Meiyan Yang, Ruifang Shen, Li Shan, Yong Qian, and Chunsheng Gao*. Model drug as pore former for controlled release of water-soluble metoprolol succinate from ethylcellulose-coated pellets without lag phase: opportunities and challenges. AAPS PharmSciTech, 2015,16(1):35-44.

  [6]Yuli Wang, Jiahui Yang, Yong Qian, Meiyan Yang, Yan Qiu, Wei Huang, Li Shan, Chunsheng Gao*. Novel ethylcellulose-coated pellets for controlled release of metoprolol succinate without lag phase: characterization, optimization and in vivo evaluation. Drug Dev Ind Pharm, 2015, 41(7):1120-1129.

  [7]Zhenzhong Ge, Meiyan Yang, Yuli Wang, Li Shan, Chunsheng Gao*. Preparation and evaluation of orally disintegrating tablets of taste masked phencynonate HCl using ion-exchange resin, Drug Dev Ind Pharm, 2015, 41(6):934-941.

  [8]Yunzhou Fan, Meiyan Yang, Yuli Wang, Yanyou Li, Yuanda Zhou, Xiaoping Chen, Li Shan, Jun Wei, Chunsheng Gao*. Preformulation characterization and in vivo absorption in beagle dogs of JFD, a novel anti-obesity drug for oral delivery. Drug Dev Ind Pharm, 2015, 41(5):801-811.

  [9]Meiyan Yang, Shaolong He, Yunzhou Fan, Yuli Wang, Zhenzhong Ge, Li Shan, Wei Gong, Xiaoli Huang, Youzhi Tong, Chunsheng Gao*. Microenvironmental pH-modified solid dispersions to enhance the dissolution and bioavailability of poorly water-soluble weakly basic GT0918, a developing anti-prostate cancer drug: Preparation, characterization and evaluation in vivo. Int J Pharm, 2014, 475(1/2):97-109.

  [10]Meiyan Yang, Si Xie, Qiu Li, Yuli Wang, Xinyi Chang, Li Shan, Lei Sun, Xiaoli Huang, Chunsheng Gao*. Effects of polyvinylpyrrolidone both as a binder and pore-former on the release of sparingly water-soluble topiramate from ethylcellulose coated pellets. Int J Pharm, 2014, 465(1/2), 187-196.

7. 专利(Patents):发明人,专利名称,授权时间,授权国别,专利号

  [1]李松,高春生等,Combination product comprising phentermine and topiramate, and preparation method thereof,授权日2016.08.23,美国,专利号US9421188B2

  [2]高春生等,一种美托洛尔的缓释药物组合物及其制备方法,授权日2016.09.08,中国,专利号ZL 201210339374.7

  [3]高春生等,穿琥宁口服药物组合物及其制备方法,授权日2014.04.16,中国,专利号ZL201110115171.5

  [4]高春生等,一种氨溴索注射剂及其制备方法,授权日2012.03.14,中国,专利号ZL201010195712.5

  [5]高春生等,一种美托洛尔缓释药用组合物及其制备方法,授权日2011.03.30,中国,专利号ZL 2006101458332

  [6]高春生等,含巴戟天寡糖提取物的制剂的制备方法,授权日2007.10.17,中国,专利号ZL 200410056935.8

  [7]高春生等,抗晕动症的盐酸苯环壬酯口崩和/或口溶固体制剂,授权日2006.11.18,中国,专利号ZL 200310103553.1

  [8]高春生等,Metoprolol sustained-release composition and preparation method thereof,申请日2015.6.23,美国,专利号USP15/320200

8. 奖励(Awards):所有获奖人,获奖项目名称,奖励机构,奖励类别,奖励等级,颁奖年份

  [1]高春生(排名第6)等,FH特效药物与医学防护核心技术研究及应用,国务院, 国家科技进步奖,一等奖,2016.

  [2]高春生(排名第3)等,我军SJXDJZD防治特效药产业化创新及其速救技术研究,总后勤部卫生部, 军队科技进步奖,一等奖,2014.