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田智勇

时间:2017年05月17日    来源:    作者:    阅读:

1. 个人信息(Personals):男,1968.03,博士,副教授,tzynew@henu.edu.cn

2. 受教育经历 (Educational Experience)(从大学本科开始,按时间倒排序):

  2005.3-2009.3  天津大学应用化学专业 博士研究生

  2001.9-2004.6  河南中医学院中药专业 硕士研究生

3. 工作经历(Professional Experience)(按时间倒排序):

  2003. 7至今 河南大学药学院 副教授;

4. 研究兴趣(Research Interests):1)药物合成;2) 小分子与生物大分子相互作用研究5. 承担项目情况:

  (1)河南省重点科技攻关项目,132102310026,芳香酰亚胺衍生物合成、生物活性, 2013/01-2015/12,5万元,已结题、主持

  (2)中国博士后科学基金第四十九批项目,20110490991,萘酰亚胺衍生物合成及其抗肿瘤活性评价, 2011/05-2014/11,3万元,已结题,主持。

  (3)河南省自然科学与基础前沿项目,112300410181、新型萘酰亚胺衍生物抗肿瘤活性及其作用机制研究,2011/01-2014/10,0 万元,已结题,主持

6. 代表性论文(Publications)

  第一作者论文

  (1) Tian, Zhiyong,Huang, Yingying,Zhang, Yan,Song, Lina,Qiao, Yan,Xu, Xuejun,Wang, Chaojie, Spectroscopic and molecular modeling methods to study the interaction between naphthalimide-polyamine conjugates and DNA, Journal of Photochemistry and Photobiology B-Biology,2016.5.01,158:1~15.

  (2) Tian, Zhi-Yong,Song, Li-Na,Zhao, Yuan,Zang, Feng-Lei,Zhao, Zhong-Hua,Chen, Nan-Hao,Xu, Xue-Jun,Wang, Chao-Jie,Spectroscopic study on the Interaction between naphthalimide-polyamine conjugates and bovine serum albumin (BSA),Molecules,2015.9.01,20(9):16491~16523.

  (3) Tian, Zhiyong,Zang, Fenglei,Luo, Wen,Zhao, Zhonghua,Wang, Yuegiao,Xu, Xuejun ,Wang, Chaojie, Spectroscopic study on the interaction between mononaphthalimide spermidine (MINS) and bovine serum albumin (BSA),Journal of Photochemistry and Photobiology B: Biology,2015.1.01,142:103~109.

  (4) Tian, Zhiyong,Zhao, Zhonghua,Zang, Fenglei,Wang, Yueqiao,Wang, Chaojie, Spectroscopic study on the interaction between naphthalimide-polyamine conjugates and DNA,Journal of Photochemistry and Photobiology B-Biology,2014.9.5,138:202~210.

  (5) Tian, Zhi-Yong,Li, Jing-Hua,Li, Qian,Zang, Feng-Lei,Zhao, Zhong-Hua,Wang, Chao-Jie, Study on the synthesis, biological activity and spectroscopy of naphthalimide-diamine conjugates,molecules,2014.6.01,19(6):7646~7668.

  (6) 田智勇,苏雷朋,谢松强,赵瑾,王超杰,萘酰亚胺-多胺缀合物的合成、生物活性和荧光光谱,有机化学,2013.2.01,(07):1514~1521.

  (7) Tian, Zhi-yong,Xie, Song-qiang,Mei, Zi-hou,Zhao, Jin,Gao, Wen-yuan,Wang, Chao-jie, Conjugation of substituted naphthalimides to polyamines as cytotoxic agents targeting the Akt/mTOR signal pathway,Organic & Biomolecular Chemistry,2009.01.01,7(22):4651~4660.

  (8) Tian, Zhi-yong,Xie, Song-qiang,Du, Yao-wu,Ma, Yuan-fang,Zhao, Jin,Gao, Wen-yuan,Wang, Chao-jie, Synthesis, cytotoxicity and apoptosis of naphthalimide polyamine conjugates as antitumor agents,European Journal of Medicinal Chemistry,2009.1.01,44(1):393~399

  (9) Tian, Zhi Yong,Ma, Hong Xia,Xie, Song Qiang,Wang, Xue,Zhao, Jin,Wang, Chao Jie,Gao, Wen Yu, Synthesis, DNA binding and topoisomerase inhibition of mononaphthalimide homospermidine derivatives,Chinese Chemical Letters,2008.5.01,19(5):509~512.

  (10) Tian, Zhi-Yong,Du, Gang-Jun,Xie, Song-Qiang,Zhao, Jin,Gao, Wen-Yuan,Wang, Chao-Jie, Synthesis and bioevaluation of 5-fluorouracil derivatives,Molecules,2007.11.01,12(11):2450~2457.

  (11) Zhiyong Tian,Luyao Zhao,Huanyang Dong,Yan Zhang,Yijuan  Zhang,Qianlei Ren,Shuangyu Shao,Yingying Huang,Lina Song,Tao Guo,Xuejun Xu,Chaojie Wang, Study on the interaction of anthracenyl-methyl homospermidine conjugate (ANTMHspd) with DNA by spectroscopic methods,Journal of Photochemistry and Photobiology B: Biology,2017.03.02,169:27~34