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庞晓斌

时间:2017年05月17日    来源:    作者:    阅读:

1. 个人信息(Personals):性别,出生日期,最终学历,职称,职务。Email:

  庞晓斌,男,1973.04.11,博士,教授,博士生导师。河南大学实验动物中心主任。pxb@vip.henu.edu.cn

2. 受教育经历 (Educational Experience) (从大学本科开始,按时间倒排序):

  2003.09–2006.06,吉林大学,生物化学与分子生物学,博士

  2000.09–2003.07,吉林大学,遗传育种,硕士

  1992.09–1996.07,内蒙古民族大学,农学,学士

3. 工作经历(Professional Experience)(按时间倒排序):

  2015.12-至今,河南大学,药学院,教授

  2008.11-2015.12,河南大学,药学院,副教授

  2006.06-2008.10,河南大学,药学院,讲师

  1996.07-2000.09,内蒙古民族大学,植物科学学院,助教

4. 研究兴趣(Research Interests):

  中药药效物质基础与新药开发;基于当今传统的治疗缺血性中风中药,对其有效成分及其抗脑缺血的分子机制进行研究,期望从传统治疗缺血性中风的中药中,探索抗脑缺血中风的分子机制,为抗脑缺血中风新药的发现奠定基础。

  疫苗和抗体的研究;针对当今AD主动免疫治疗所面临的问题入手,设计开发拥有自身特点的候选AD亚单位疫苗,使疫苗既能诱导出高水平的Aβ特异性抗体,又能避免Th1型免疫反应带来的副作用,期望得到一种能产生针对Aβ寡聚体特异性抗体的疫苗。

5. 承担项目情况(Financial Supports)(包括项目名称,批准号,金额,起止年月,基金来源,本人角色)

  [1] 脉络宁注射液调控星形胶质细胞谷氨酸转运体GLT-1参与脑缺血后神经血管单元功能重塑的机制研究,批准号:81541072,10万元,2016.01-2016.12,国家自然科学基金,主持。

  [2] 消栓通络有效成分组基于"神经血管单元(NVU)"治疗缺血性中风的机制研究,批准号:81273652,72万元,2013.1-2016.12,国家自然科学基金,主持。

6. 代表性论著(Publications)

  [1] Enze Wang, Lanfang Pang, Yanmei Zhou, Junli Zhang, Fang Yu, Han Qiao, Xiaobin Pang. A high performance Schiff-base fluorescent probe for monitoring Au3+ in zebrafish based on BODIPY. Biosensors and Bioelectronics, 2016, 17: 812–817.

  [2] Xinmei Xie,Lin Wang,Wenliang Yang,Ruishuang Yu,Qingli Li,Xiaobin Pang*. Co-administration of antigen with chemokine MCP-3 or MDC/CCL22 enhances DNA vaccine potency[J]. Invest New Drug, 2015, 33(4): 810–815.

  [3] Zhao Yan, Chu Xiao, Pang XiaoBin, Wang ShaoHua, DU GuanHua. Antithrombotic effects of the effective components group of Xiaoshuantongluo formula in vivo and in vitro. Chinese Journal of Natural Medicines. 2015, 13(2): 0099-0107.

  [4] Qiang G, Xue S, Yang J J, Du G, Pang X, Li X, Goswami D, Griffin P R, Ortlund E A, Chan C BandYe K. Identification of a small molecular insulin receptor agonist with potent antidiabetes activity. Diabetes, 2014, 63(4): 1394-1409. SCI (一区).

  [5] Li Q, Xu K X, Song P, Dai Y P, Yang L and Pang X B*. Novel enantioselective fluorescent sensors for malate anion based on acridine. Dyes and Pigments, 2014, 109: 169-174.

  [6] Xu K X, Xie X M, Kong H J, Li P, Zhang J L and Pang X B*. Selective fluorescent sensors for malate anion using the complex of phenanthroline-based Eu(III) in aqueous solution. Sensors and Actuators B-Chemical, 2014, 201: 131-137.

  [7] Yu Y Z, Wang W B, Chen A, Chang Q, Liu S, Zhao M, Wang S, Qiu W Y, Pang X B*, Xu Q and Sun Z W. Strikingly reduced amyloid burden and improved behavioral performance in Alzheimer's disease mice immunized with recombinant chimeric vaccines by hexavalent foldable Abeta(1)(-)(1)(5) fused to toxin-derived carrier proteins. J Alzheimers Dis, 2014, 41(1): 243-260.

  [8] Pang X B, Xie X M, Zhao Q H, Wang S BandDu G H. A novel accurate method of human protein tyrosine phosphatase 1B inhibitors high-throughput screening. Acta Pharmacologica Sinica, 2013, 34: 45-46.

  [9] Li L, Pang X B, Chen B N, Gao L, Wang L, Wang S B, Liu D PandDu G H. Pinocembrin inhibits angiotensin II-induced vasoconstriction via suppression of the increase of [Ca2+]i and ERK1/2 activation through blocking AT(1)R in the rat aorta. Biochem Biophys Res Commun, 2013, 435(1): 69-75.

  [10] Wang S B, Pang X B, Gao M, Fang L H and Du G H. Pinocembrin protects rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids. Chinese Journal of Natural Medicines, 2013, 11(3): 207-213.

  [11] Guo Y W, Guo H L, Li X, Huang L L, Zhang B N, Pang X B, Liu B Y, Ma L Q and Wang H. Two type III polyketide synthases from Polygonum cuspidatum: gene structure, evolutionary route and metabolites. Plant Biotechnology Reports, 2013, 7(3): 371-381.

  [12] Yu Y Z, Wang S, Bai J Y, Zhao M, Chen A, Wang W B, Chang Q, Liu S, Qiu W Y, Pang X B*, Xu Q, and Sun Z W. Effective DNA epitope chimeric vaccines for Alzheimer's disease using a toxin-derived carrier protein as a molecular adjuvant. Clin Immunol, 2013, 149(1): 11-24.

  [13] 王琳, 余瑞双, 杨文亮, 栾淑娟, 秦本凯, 庞晓斌*, 杜冠华. 紫杉醇载药胶束对人肺癌A549细胞增殖与凋亡的影响[J]. 药学学报, 2015,50(10),1240-1245.

  [14] 谢欣梅, 庞晓斌*, 赵艳, 王保全, 陈若芸和杜冠华. 消栓通络有效成分组对氧糖剥夺损伤原代培养神经元的保护作用. 药学学报, 2014(08): 1130-1135 .

  [15] 庞晓斌, 谢欣梅, 赵清辉. 红景天苷对人肝癌HepG2细胞增殖及凋亡的影响. 中国药学杂志, 2014(03): 195-198.

  [16] 庞晓斌, 谢欣梅, 王海燕和王保全. 脉络宁对大鼠脑缺血再灌注损伤的保护作用及其机制研究. 中国中药杂志, 2014, 39(4): 721-725.

7. 专利(Patents):发明人,专利名称,授权时间,授权国别,专利号

  庞晓斌,一种复方替米沙坦氢氯噻嗪药物组合物及其制备方法,2014,中国,ZL201210354977.4。