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万绍贵

时间:2017年05月17日    来源:    作者:    阅读:

1.个人信息:

  男,1979年8月出生,博士,博士生导师,九三学社社员,河南大学黄河学者特聘教授,主要从事肿瘤分子标志物和液体活检技术开发等方面的研究。已在国际主流期刊上总共发表SCI论文30多篇,其中包括Gastroenterology, International Journal of Cancer, European Journal of Cancer, Carcinogenesis, Liver International, Scientific Reports,  Molecular Cancer 和Cancer Science等,当前总被引500多次,h-index为13,i10-index为17。Email:shaoguiwan@126.com

2. 受教育经历 

  2003/09-2006/07,中国科学院昆明动物所,博士

  2000/09-2003/07,江西农业大学动物科技学院,硕士

  1996/09-2003/07,江西农业大学动物科技学院,学士

3. 研究工作经历

  2013/09 - 至今     河南大学药学院, 教授

  2013/07 - 2013/09  第四军医大学基础部教学与实验中心,合作研究

  2010/07 - 2013/07  美国托马斯杰斐逊大学Kimmel癌症研究中心, 博士后

  2008/08 - 2010/06  美国托马斯杰斐逊大学药理系,博士后

  2006/09 - 2008/07  美国美国俄亥俄州立大学癌症研究中心,博士后

4. 研究方向

  基因检测与个体化临床用药(PCR-based gene detection and tailored patient treatment)

  游离核酸与液体活检(Circulating cell-free nucleic acids and liquid biopsy)

  线粒体DNA生物学及其免疫功能 (Mitochondrial DNA and its immune functions)

  欢迎对肿瘤分子标志物以及体外诊断行业有兴趣的广大同学加入我们的科研团队!

5. 主持承担的主要科研项目(总计在研经费456万元):

  国家自然科学基金NSFC-河南省联合项目,基金号:U1604167;项目名称:游离线粒体IMOs作为肝癌液体活检标志物的临床应用及功能研究;资助金额:46万元;起止时间:2017.1- 2019.12;主持人(在研)

  河南省高校科技创新人才支持计划,计划编号:15HASTIT035;研究方向:无创分子标志物的发掘及其转化医学研究;资助经费:60万元;资助期限:2015.1-2017.12;主持人(在研)

  河南大学杰出青年科研人才培育计划,资助金额: 300万元,起止时间:2014.8- 2019.7;主持人 (在研)

  河南大学黄河学者启动基金,资助金额: 50万元,起止时间:2013.11-2017.10;主持人 (在研)

  国家自然科学基金青年项目,基金号: 81201578; 项目名称:缺锌诱导的DNA异常甲基化在食管鳞状上皮细胞癌变过程中的机理研究;资助金额: 23万元;起止时间:  2013.1-2015.12;主持人 (已结题)

6.主要论著

  第一作者及通讯作者SCI论文

  [1]Wan S, Hann HW, Lai Y, Hann RS, Ye Z, Wang  C, Li L, Myers RE, Li B, Xing J, Yang Y. Prospective and longitudinal evaluations of telomere length of circulating DNA as a risk predictor of hepatocellular carcinoma in HBV patients. Carcinogenesis. 2017 Apr; 38(4): 439-446. (IF=4.87, SCI 二区)

  [2]Bao D, Ba Y, Zhou F, Zhao J, Yang Q, Ge N, Guo X, Wu Z, Zhang H, Wan S*, Xing J*. Alterations of telomere length and mtDNA copy number are associated with overall survival in hepatocellular carcinoma patients treated with transarterial chemoembolization. Cancer Chemotherapy and Pharmacology. 2016 Aug; DOI: 10.1007/s00280-016-3128-1. (通讯作者) (IF=2.824, SCI 三区)

  [3]Li L, Hann HW, Wan S, Hann R, Wang C, Lai Y, Ye X, Evans A, Myers R, Ye Z, Li B, Xing J, Yang H*. Cell-free circulating mitochondrial DNA content and risk of hepatocellular carcinoma in patients with chronic HBV infection. Scientific Reports. 2016 Apr; 6:23992. (共同第一作者)(IF=5.58, SCI二区)

  [4]Dong G, He X, Chen Y, Cao H, Wang J, Liu X, Wang S, Wan S*, Xing J*. Genetic variations in genes of metabolic enzymes predict post operational prognosis of patients with colorectal cancer. Molecular Cancer. 2015 Sep; 17 (14):171.(*通讯作者)(IF=4.257, SCI二区)

  [5]Wan S, Wu Y, Zhou X, Chen Y, An J, Yu X, Zhang H, Yang H*, Xing J*. Polymorphisms in genes of tricarboxylic acid cycle key enzymes are associated with early recurrence of hepatocellular carcinoma. PLoS One. 2015 Apr; 10(4):e0124471. (IF=3.234, SCI三区)

  [6]Dong H, Bao D, Guo X, Hu J, Li X, Wan S*, Xing J*. Effect of thymidylate synthase gene polymorphism on the response to chemotherapy and clinical outcome of non-small cell lung cancer patients. Tumor Biology. 2015 Apr; 36 (9), 7151-7157. (*通讯作者)(IF=3.611, SCI三区)

  [7]Wu YS, Bao DK, Dai JY, Chen C, Zhang HX, Yang YF, Xing JL, Huang XJ*, Wan SG*. Polymorphisms in genes of the De Novo lipogenesis pathway and overall survival of hepatocellular carcinoma patients undergoing transarterial chemoembolization. Asian Pacific Journal of Cancer Prevention. 2015 Mar; 16 (3):1051-1056. (*通讯作者) (IF=2.514, SCI四区)

  [8]Hann HW, Wan S, Lai Y, Hann RS, Myers RE, Patel F, Zhang K, Ye Z, Wang C, Yang H*. AST to platelet ratio index as a prospective predictor of hepatocellular carcinoma risk in patients with chronic HBV infection. Journal of Gastroenterology and Hepatology. 2015 Jan; 30 (1):131-8.(共同第一作者)(IF=3.504,SCI三区)

  [9]Du X, Wan S,Chen Y, Qu P, Huang X, Yu X, Yang H, Zhang Y*, Xing J*. Genetic variants in genes of tricarboxylic acid cycle key enzymes predict postsurgical overall survival of patients with hepatocellular carcinoma. Annals of Surgical Oncology. 2014 Dec; 21(13):4300-7.(共同第一者)(IF=3.93, SCI二区)

  [10]Yang Y, Fei F, Song Y, Li X, Zhang Z, Fei Z, Su H*, Wan S*. Polymorphisms of EpCAM Gene and Prognosis of non-small cell lung cancer in Han Chinese. Cancer Science. 2014 Jan;105:89-96. (*通讯作者) (IF=3.523,SCI二区)

  [11]Wan S. Lai Y, Myers RE, Li B, Palazzo JP, Burkart AL, Chen G, Xing JL, Yang H*. Post-diagnosis hemoglobin change associates with the overall survival of multiple malignancies-Results from a 14-year hospital-based cohort of lung, breast, colorectal, and liver cancers. BMC Cancer. 2013 Jul 10; 13:340. (IF=3.362, SCI三区)

  [12]Wan S, Lai Y, Myers RE, Li B, Hyslop T, London J, Chatterjee D,Palazzo JP, Burkart AL, Zhang K, Xing J, Yang H*. Preoperative platelet count associates with survival and distant metastasis in surgically resected colorectal cancer patients. Journal of Gastrointestinal Cancer.2013 Sep; 44(3):293-304.

  [13]Wan S, Hann HW, Myers R, Fu X, Hann H, Kim SH, Tang H, Xing J, Yang H*. Telomere length in circulating serum DNA as a novel non-invasive biomarker for cirrhosis risk: a nested case control analysis. Liver International.2012 Sep; 32(8):1233-41. (IF=4.85,SCI二区)

  [14]Fu X, Wan S, Hann HW, Myers R, Hann RS, Au J, Chen B, Xing J, Yang H*. Relative telomere length: a novel non-invasive biomarker for the risk of non-cirrhotic hepatocellular carcinoma in HBV patients. European Journal of Cancer.2012 May; 48(7):1014-22 (共同第一者). (IF=5.417, SCI二区)

  [15]Hann HW, Wan S, Myers R, Hann RS, Xing J, Chen B, Yang H*. Comprehensive analysis of common serum liver enzymes as prospective predictors of hepatocellular carcinoma in HBV patients-results of a clinic-based cohort. PLoS One. 2012; 7(10): e47687.(共同第一作者). (IF=3.234,SCI三区)

  [16]Wan S, Civan J, Rossi S, Yang H*. Profiling HBV integrations in hepatocellular carcinoma. Hepatobiliary Surgery and Nutrition. 2012 Oct; 1:19. (Invited commentary)

  [17]Wan SG, Taccioli C, Jiang Y, Chen H, Smalley KJ,Huang K, Liu XP, Farber JL,Croce CM, Fong LY*. Zinc deficiency activates S100A8 inflammation in the absence of COX-2 and promotes murine oral-esophageal tumor progression. International Journal of Cancer. 2011 Jul 15; 129 (2):331-45. (IF=5.085, SCI二区)

  [18]Wan SG, Jin Y, Lee WH, Zhang Y*. A snake venom metalloproteinase that inhibited cell proliferation and induced morphological changes of ECV304 cells. Toxicon. 2006, 47(4):480-489. (IF=2.492,SCI三区)

  [19]Wan SG, Jin Y, Lee WH, Zhang Y*. Cloning of Two Novel P-III Class Metalloproteinases from Trimeresurusstejnegeri Venom Gland. Toxicon. 2006, 47(4):465-472. (IF=2.492,SCI三区)

  共同作者的SCI论文

  [20]Taccioli C, Wan SG, Liu CG, Alder H, Volinia S, Farber JL, Croce CM and Fong LYY. Zinc replenishment reverses overexpression of the proinflammatory mediator S100A8 and esophageal preneoplasia in the rat. Gastroenterology.2009,136 (3):953-66. (IF=16.716,SCI一区)

  [21]Xing J, Wan S, Zhou F, Qu F, Li B, Myers RE, Fu X, Palazzo JP, He X, Chen Z, Yang H. Genetic Polymorphisms in Pre-microRNA Genes as Prognostic Markers of Colorectal Cancer. Cancer Epidemiology, Biomarkers & Prevention. 2012 Jan; 21(1):217-27. (IF=4.125,SCI二区)

  [22]Dai J, Wan S, Zhou F, Myers R, Guo X, Fu X, Palazzo J, Dou K, Yang H, Xing J. Genetic polymorphism in a VEGF-independent angiogenisis gene ANGPT1 and overall survival of colorectal cancer patients after surgical resection. PLoS One.2012;7(4):e34758. (IF=3.234,SCI二区)

  [23]Dong G, Guo X, Fu X, Wan S, Zhou F, Myers R, BaoG, Burkart A, Yang H, Xing J. Potentially functional genetic variants in KDR gene as prognostic markers in patients with resected colorectal cancer. Cancer Science.2012 Mar;103(3):561-8.(IF=3.523,SCI二区)

  [24]Yuan P, Wang S, Zhou F, Wan S, Yang Y, Huang X, Zhang Z, Zhu Y, Zhang H, Xing J.Functional polymorphisms in NPAS2 gene are associated with overall survival in TACE-treated hepatocellular carcinoma patients.Cancer Science. 2014 Apr; 105(7):825-32. (IF=3.523,SCI二区)

  [25]Wang C, Hann HW, Hann RS, Wan S, Myers RE, Ye Z, Xing J, Yang H.Circulating Mitochondrial DNA Content Associated with the Risk of Liver Cirrhosis: A Nested Case-Control Study. Digestive Diseases Sciences. 2015 Jan; 60(6):1707-15.(IF=2.613,SCI四区)

  [26]Chen Y, Qu F, He X, Bao X, Liu X, Wan S, Xing J.Short leukocyte telomere length predicts poor prognosis and indicates altered immune functions in colorectal cancer patients. Annals of Oncology, 2014 Apr. 25 (4): 869-876. (IF=7.04,SCI二区)

  [27]Yu X, Ge N, Guo X, Shen S, Liang J, Huang X, Wan S, Xing J, Huang Q, Yang Y. Genetic variants in the epcam gene is associated with the prognosis of transarterial chemoembolization treated hepatocellular carcinoma with portal vein tumor thrombus. PLoS One. 2014 Apr 9;9(4):e93416. (IF=3.234,SCI二区)

  [28]Liu B, Liu Q, Song Y, Li X, Wang Y, Wan S, Zhang Z, Su H. Polymorphisms of HIF1A gene are associated with prognosis of early stage non-small-cell lung cancer patients after surgery. Medical Oncology. 2014 Apr;31(4):877.(IF=2.634,SCI四区)

  [29]Wang S, Chen Y, Qu F, He S, Huang X, Jiang H, Jin T, Wan S, Xing J. Association between leukocyte telomere length and glioma risk: a case-control study. Neuro-Oncology. 2013Dec22. (IF=5.562,SCI二区)

  [30]Hann HW, Fu X, Myers RE, Hann RS, Wan S, Kim SH, Au N, Xing J, Yang H. Predictive value of alpha fetoprotein in the long-term risk of developing hepatocellular carcinoma in patients with hepatitis B virus infection- results from a clinic-based longitudinal cohort. European Journal of Cancer.2012 Mar; (IF=5.417,SCI二区)

  [31]Lei W, Huang Y, Zhang Y, Yu G, Wan S, Lee W, Zhang Y. The frog trefoil factor Bm-TFF2 activates human platelets via Gq and G12/13 signaling pathway. Toxicon. 2012 Jan; 59(1):104-9. (IF=2.492,SCI三区)

  [32]Xing J, Myers RE, He X, Qu F, Zhou F, Ma X, Hyslop T, Bao G, Wan S, Yang H, Chen Z. GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis. European Journal of Cancer. 2011 Jul 47(11):1699-707. (IF=5.417,SCI二区)

  [33]Zhang J, Zhang Y, Wan SG, Wei SS, Lee WH, Zhang Y.Bm-TFF2, a trefoil factor protein with platelet activation activity from frog Bombina maxima skin secretions. Biochemical and Biophysical Research Communications.2005, 330: 1027–1033. (IF=2.297,SCI四区)