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段少峰

时间:2017年05月02日    来源:    作者:    阅读:

1. 个人信息(Personals):

  男,1973.01,教授,河南大学黄河学者特聘教授,有机化学博士,药剂学带头人,dsf_2007@163.com; sduan@henu.edu.cn.

2. 受教育经历 (Educational Experience) (从大学本科开始,按时间倒排序):

  2002.08-2007.10,新墨西哥州立大学,化学与生物化学系,博士(有机化学)

  1998.09-2000.10,华东理工大学,精细化工研究所,攻读博士

  1995.09-1998.04,南京理工大学,化工学院,硕士(应用化学)

  1991.09-1995.07,南京理工大学,化工学院,本科(精细化工)

3. 工作经历 (Professional Experience) (按时间倒排序):

  2015.09-至今,河南大学药学院,教授,黄河学者特聘教授

  2010.05-2015.08,美国堪萨斯大学药学院,副研究员

  2008.11-2010.05,美国堪萨斯大学药学院,博士后

  2007.10-2008.11,美国堪萨斯大学药学院,博士后

4. 研究兴趣(Research Interests):

  研究方向:1)小分子抗癌药的设计与合成;2)纳米高分子药物载体的设计与合成;3)抗癌前药的合成及药物控释。

  5、承担项目情况 (Financial Supports) (包括项目名称,批准号,金额,起止年月,基金来源,本人角色)

  [1]基于金纳米棒的新型一氧化氮供体前药的合成及其在抗乳腺癌方面的应用研究,162300410044,10万,2017.01-2019.12,河南省自然科学基金,主持。

  [2]河南大学黄河学者启动基金, 50万元,2015.09-2020.08,河南省博士后科研项目,主持。

6. 代表性论著 (Publications)

  1)期刊论文 (Journal Articles) :所有作者(通讯作者以“*”标出),论文标题,期刊名称,卷 (期) ,pp起始页码,发表年份

  [1]Shengnan Huang#, Shaofeng Duan#, Jing Wang, Shijin Bao, Xiaojing Qiu, Chunming Li, Ying Liu, Lijuan Yan, Zhenzhong Zhang,Yurong Hu. Folic Acid Mediated Functionalized Gold Nanocages for Targeted Delivery of Anti-miR-181b in Combination of Gene Therapy and Photothermal Therapy against Hepatocellular Carcinoma. Advanced Functional Materials 2016 26(15), 2532-2544

  [2]Solomon Z Okbazghi, Apurva S More, Derek R White, Shaofeng Duan, Ishan S Shah, Sangeeta B Joshi, C Russell Middaugh, David B Volkin, Thomas J Tolbert. Production, Characterization, and Biological Evaluation of Well-Defined IgG1 Fc Glycoforms as a Model System for Biosimilarity Analysis. J Pharm. Sci. 2016 105(2), 559-74.

  [3]Yunqi Zhao, Ti Zhang#, Shaofeng Duan#, Neal M Davies, M Laird Forrest. CD44-tropic polymeric nanocarrier for breast cancer targeted rapamycin chemotherapy. Nanomedicine 2014 10(6), 1221-30.

  [4]Lohrman, Jessica; Liu, Yueying; Duan, Shaofeng; Zhao, Xiaoyong; Wuttig, Manfred; Ren, Shenqiang; All Conjugated Copolymer Excitonic Multiferroics. Advanced Materials 2013 25 (5), 783-787.

  [5]Ndolo, Rosemary A.; Luan, Yepeng; Duan, Shaofeng; Forrest, M. Laird; Krise, Jeffrey P. Lysosomotropic properties of weakly basic anticancer agents promote cancer cell selectivity in vitro. PLoS One  2012 7(11), e49366.

  [6]SM Cohen, R Mukerji, S Duan, S Cai, ML Forrest, MS CohenM. Laird Forrest. A Novel Nanocarrier Delivery System for Doxorubicin with Improved Tumor Response and Reduced Systemic Toxicity in Advanced Pediatric Non-Hodgkin Lymphoma. Journal of Surgical Research. 2012 172 (2), 317.

  [7]Yunqi Zhao#, Shaofeng Duan#, Xing Zeng, Chunjing Liu, Benyi Li, Neal M. Davies, M Laird Forrest. Prodrug Strategy for PSMA-targetted Delivery of TGX-221 to Prostate Cancer Cells. Molecular Pharmaceutics. 2012, 9, 1705−1716.

  [8]Taryn R. Bagby#, Shaofeng Duan#, Shuang Cai, Laird Forrest. Functional lymphatic imaging using negatively charged star polymer architectures grafted with near-infrared dye. European Journal of Pharmaceutical Sciences  2012, 47(1), 287-294.

  [9]Taryn R. Bagby, Shuang Cai, Shaofeng Duan, Sharadvi Thati, Aires, Daniel J., Laird Forrest. Impact of molecular weight on lymphatic drainage of a biopolymer-based imaging agent. Pharmaceutics  2012, 4(2), 276-295.

  [10]Shaofeng Duan, Shuang Cai, Yumei Xie, M. Laird Forrest. Ester star polymers as controlled drug release carriers for cisplatin and nitric oxide. Journal of Polymer Science Part A: Polymer Chemistry 2012, 50, 2715–2724.

  [11]Shaofeng Duan, Shuang Cai, Qiuhong Yang, M. Laird Forrest. Multi-arm polymeric nanocarrier as a nitric oxide delivery platform for chemotherapy of head and neck squamous cell carcinoma. Biomaterials  2012, 33, 3243-3253.

  [12]Yepeng Luan, Qiuhong Yang, Yumei Xie, Shaofeng Duan, M.L Forrest. A Sensitive Near-Infrared Fluorescent Probe for Caspase-mediated Apoptosis: Synthesis and Application in Cell Imaging. Drug Discoveries & Therapeutics  2011, 5(5), 220-226.

  [13]Rajesh Kumar Patti, Shaofeng Duan, Zhipeng Wang, James W. Herndon. Preparation of phenalenes and hydronaphthacenes through tandem alkyne Fischer–carbene complex coupling and inter- or intra-molecular Diels–Alder reactions. Tetrahedron Lett. 2011, 52(32), 4182-4185.

  [14]Rajesh Kumar-Patti, Shaofeng Duan, Alejandro Camacho-Davila, Kris Waynant, Kenneth A Dunn, James W Herndon. Synthesis of hydronaphthalenes through coupling of enyne carbonyl compounds that contain pendant alkene groups with Fischer carbene complexes. Tetrahedron Lett. 2010, 51(28), 3682-3684.

  [15]Xie, Yumei, Duan, Shaofeng, Forrest, M. Laird. Alkyne- and 1, 6-elimination-succinimidyl carbonate-terminated heterobifunctional poly (ethylene glycol) for reversible "click" PEGylation. Drug Discoveries & Therapeutics 2010, 4(4), 240-245.

  [16]Sandipan Sinha, Lei Zhang, Shaofeng Duan, Todd Williams, Josef Vlasak, Roxana Lonescu, Elizabeth Topp. Effect of protein structure on deamidation rate in the Fc fragment of an IgG1 monoclonal antibody. Protein Science 2009, 18(8), 1573-1584.

  [17]Shaofeng Duan, Ranjan Jana, Jon Tunge. “Lewis acid-catalyzed diastereoselective hydroarylation of benzylidene malonic esters” J. Org. Chem. 2009, 74, 4612–4614.

  [18]Shaofeng Duan, Dilip K. Sinha-Mahapatra, James W. Herndon. “Synthesis of Nanphthalenes through three-component coupling of alkynes, Fischer carbene complexes and Benzaldehyde Hydrozones via Isoindole intermediates” Org. Lett. 2008, 10, 1541-1544.

  [19]Shaofeng Duan, Karen Cress, Kris Waynant, Elias Ramos-Miranda, James W. Herndon. “Synthesis of alkylidenephthalans through fluoride-induced cyclization of electron-deficient 2-siloxymethylphenylacetylene derivatives” Tetrahedron 2007, 63, 2959-2965.

  [20]Binay K.Ghorai, Shaofeng Duan, Delu jiang, James W. Herndon. “Coupling of β-Cyanocarbene-Chromium Complexes with 2-Alkynylbenzoyl Derivatives: A (5+5)-Cycloaddition Approach to Phenanthridines” Synthesis 2006, 21, 3661-3669.

  [21]Liu, Xiangxuan, Duan, Shaofeng, Ling, Yue, Yang, Xujie, Lu, Lude, Wang, Xin. Curing reaction and thermal property of TiO2/BMI resin. Nanjing Ligong Daxue Xuebao 1998, 22(3), 244-247.

7. 专利(Patents):发明人,专利名称,授权时间,授权国别,专利号

  [1]Forrest, M. L., Zhang, T., Senadheera, S. S. P. N., Aires, D., Zhao, Y., & Duan, S., et al. TARGETED MTOR INHIBITORS,2016.03,美国,US20160279108

  [2]M. Laird Forrest, Shaofeng Duan, Shuang Cai, Ti Zhang, Qiuhong Yang. Drug and imaging agent delivery compositions and methods,2013.07,美国,WO2013109907 (A1).